ArticleFrontiers in nutrition2025
Unveiling the therapeutic mechanisms of Saorilao-4 decoction in pulmonary fibrosis through metabolomics and transcriptomics.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pulmonary fibrosis (PF) is a challenging and intricate lung ailment to treat. Saorilao-4 decoction (SRL) is a traditional Mongolian medicine remedy frequently utilized in the management of lung disorders. This study employed transcriptomics and metabolomics to explore the molecular mechanisms of SRL in the bleomycin-induced PF rat model. Additionally, histopathological analysis and the assessment of serum biochemical indices were utilized to investigate the potential mitigating effects of SRL on PF. Transcriptomics and metabolomics analyses indicate that SRL primarily modulates the adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors (PPAR) signaling pathways by regulating genes such as
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