Evidence map›Paper›PMID 40860435›Full record

ArticleiMeta2025

Gut microbiota-derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation.

Chunli Wang, Zongtao Liu, Tingwen Zhou, Jiaqin Wu, Fan Feng, Shunshun Wang, Qingjia Chi, Yongqiang Sha, Shuai Zha, Songren Shu and 9 more

Abstract read
In one paragraph

Article in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
  2. Review
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  4. Nutrients · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Article
  15. Antioxidants (Basel, Switzerland) · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chunli WangHubei Shizhen Laboratory Wuhan China.ORCID https://orcid.org/0000-0001-8891-1797
Zongtao LiuDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Tingwen ZhouDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Jiaqin WuHubei Shizhen Laboratory Wuhan China.
Fan FengHubei Shizhen Laboratory Wuhan China.ORCID https://orcid.org/0000-0003-1978-2914
Shunshun WangSchool of Pharmacy Hubei University of Chinese Medicine Wuhan China.
Qingjia ChiCollege of Electrical Engineering and Automation Anhui University Hefei China.
Yongqiang ShaCenter for Precision Medicine, School of Medicine and School of Biomedical Sciences Huaqiao University Xiamen China.
Shuai ZhaHubei Shizhen Laboratory Wuhan China.
Songren ShuFuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Linghang QuHubei Shizhen Laboratory Wuhan China.
Qianqian DuSchool of Pharmacy Hubei University of Chinese Medicine Wuhan China.
Huiming YuSchool of Pharmacy Hubei University of Chinese Medicine Wuhan China.
Li YangMinistry of Education Key Laboratory for Biorheological Science and Technology, National Local Joint Engineering Lab for Vascular Implants, College of Bioengineering Chongqing University Chongqing China.
Anna MalashichevaInstitute of Cytology Russian Academy of Science Petersburg Russia.
Nianguo DongDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Fei XieDepartment of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China.
Guixue WangMinistry of Education Key Laboratory for Biorheological Science and Technology, National Local Joint Engineering Lab for Vascular Implants, College of Bioengineering Chongqing University Chongqing China.ORCID https://orcid.org/0000-0002-9192-8757
Kang XuHubei Shizhen Laboratory Wuhan China.ORCID 0000-0002-8492-2058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The involvement of gut microbiota in calcific aortic valve disease (CAVD) pathogenesis remains underexplored. Here, we provide evidence for a strong association between the gut microbiota and CAVD development. ApoE

Indexed as

butyric acidbutyrylationcalcific aortic valve calcificationglycolysislactylation

Identifiers

PMID40860435
PMCPMC12371252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.