ArticleJournal of conservative dentistry and endodontics2025
Cytotoxicity of hydraulic cement dicalcium silicate mixture of eggshell calcium and rice husk silica on fibroblast cells.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Dicalcium silicate is currently used for vital pulp therapy in dentistry. In this research, a novel dicalcium silicate hydraulic cement is expected to be biocompatible and exhibit low cytotoxicity, making it a promising material for vital pulp therapy. The basis of the cytotoxicity test is the ability of cells to survive in the presence of a given toxic compound. Objective: The objective of this study was to determine the cytotoxicity effect of a novel hydraulic cement dicalcium silicate on fibroblast cells. Methods: NIH3T3 fibroblast cells that had undergone serum starvation for 24 h were given hydraulic cement culture media of novel dicalcium silica with concentrations of 1:1, 1:2, 1:4, and Dulbecco's Modified Eagle Medium as a negative control. The cytotoxicity effect was tested at 24 and 48 h using the MTT assay. The results were analyzed using a statistical nonparametric Kruskal-Wallis test, followed by Results: There was no significant difference in the value of cell viability in the administration of a novel hydraulic cement dicalcium at various concentrations (1:1, 1:2, 1:4) against NIH3T3 fibroblast cells at 24 h of observation, with a mean of the highest viability value at a concentration of 1:4. At 48 h of observation, there was a significant difference in the value of cell viability in the administration of a novel dicalcium silicate hydraulic cement, at various concentrations (1:1, 1:2, 1:4) to NIH3T3 fibroblast cells, with the highest mean viability value treatment group at a concentration of 1:4. Conclusion: A novel dicalcium silicate hydraulic cement in various concentrations (1:1, 1:2, 1:4) did not have a cytotoxic effect on NIH3T3 fibroblast cells at 24 h and 48 h. The highest NIH3T3 fibroblast cell viability value at 24 and 48 h was observed at a concentration of 1:4.
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