ArticleJournal of conservative dentistry and endodontics2025
Comparative evaluation of antimicrobial properties of calcium hydroxide-loaded polylactic-co-glycolic acid nanoparticles and calcium hydroxide: A systematic review and meta-analysis.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- CombatingJournal of conservative dentistry and endodontics · 2026Article
- Comparison of the Antimicrobial Properties of Nanoemulsions Made from Phytosphingosine and Chitosan with a Triple Antibiotic Paste AgainstInternational journal of nanomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The aim of the study was to evaluate the antimicrobial properties of calcium hydroxide (CH)-loaded polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and CH when used as an intracanal medicament (ICM). Methods: Adhering guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis, the review was registered in the Prospective Registration of Systematic Review-CRD42023454265. Databases from January 2000 to December 2023 were examined for studies evaluating the various properties of CH-loaded PLGA NPs compared to conventional ICM-CH. Using the Cochrane risk of bias (ROB)-2 tool for randomized clinical trials (RCTs) through its domains using Review Manager (RevMan) software version 5.3, quality assessment was evaluated. Standardized mean difference (SMD) was used as a summary statistic measure with a random effect model ( Results: To fulfill eligibility criteria, six studies were included in qualitative synthesis, from which three were fit for meta-analysis. The quality assessment revealed a moderate to low ROB. The pooled estimate through SMD (0.45 [-1.17-0.27]) and the favored intervention group (CH-loaded PLGA NPs) showed that the reduction in smear layer/biofilm was more significant in the intervention group. Indicating the absence of publication bias, no presence of any heterogeneity was revealed by the funnel plot. Conclusion: It was observed that CH-loaded PLGA NPs showed improved antibacterial properties, greater dentinal tubule penetration, and a significant microbial load reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.