SynthesisFrontiers in cardiovascular medicine2025
Early life exposure to ambient particulate matter and Kawasaki disease: a systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Though numerous air pollutants have been mechanistically associated with inflammation and vascular morbidity, particulate matter (PM) is one of the pollutants with the strongest association. However, PM is generally categorized according to aerodynamic diameters between 2.5 and 10 μg m Methods: A systematic search was conducted using PubMed and EMBASE. Studies with PM included as a predictor, and Kawasaki disease as an outcome were included. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The risk of bias in the selected studies was assessed using the QUADAS-2 tool. Results: Eleven studies met the criteria for inclusion. All studies suggested an association between exposure to PM and increase risk or exacerbation of KD, though not all results reached statistical significance. Due to significant heterogeneity, pooled analyses were possible only in select studies for pre- and postnatal PM Conclusion: Particulate matter exposure is associated with an increased risk of developing and exacerbating KD, especially in populations experiencing temporary increased sensitivity and in populations with preexisting inflammatory diseases. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023468937, PROSPERO CRD42023468937.
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