Evidence map›Paper›PMID 40860360›Full record

ArticleFrontiers in cardiovascular medicine2025

Core signature of rejection-associated cytokines and chemokines in endomyocardial biopsies after heart transplantation.

Lena M-L Radomsky, Jenny F Kühne, Kerstin Beushausen, Jana Keil, Ludmilla Knigina, Yves Scheibner, Adelheid Görler, Arjang Ruhparwar, Fabio Ius, Christoph L Bara and 1 more

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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Lena M-L RadomskyInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Jenny F KühneInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Kerstin BeushausenInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Jana KeilInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
Ludmilla KniginaDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Yves ScheibnerDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Adelheid GörlerDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Arjang RuhparwarDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Fabio IusDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Christoph L BaraDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Christine S FalkInstitute of Transplant Immunology, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rejection remains a limiting factor for survival after heart transplantation (HTx), and predictive biomarkers are still missing. Therefore, we aimed to define the cytokine/chemokine microenvironment in endomyocardial biopsies (EMB) and plasma after HTx and to identify patterns that reflect ischemia/reperfusion injury as well as allograft rejection. Therefore, we hypothesize distinct cytokine/chemokine patterns in heart biopsies with histopathologically proven rejection compared with the microenvironment in unsuspicious biopsies. Methods: EMB ( Results: Regarding rejection status, distinct cytokine/chemokine patterns were identified with significantly higher concentrations of CCL4, CXCL9, and CXCL10 in EMB with acute rejection ( Conclusion: A core signature was defined for EMB with histopathologically proven AR, consisting of high concentrations of CXCL9, CXCL10, CCL3, and CCL4. This EMB chemokine signature was clearly distinct from plasma samples, arguing for a local protein microenvironment associated with AR. Further research is also needed with the help of AI to translate the different approaches for the detection and prediction of AR into clinical practice.

Indexed as

chemokinescytokinesheart transplantationmyocardial biopsiesrejection

Identifiers

PMID40860360
PMCPMC12370642

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