Evidence map›Paper›PMID 40860316›Full record

Reviewnpj health systems2025

Achieving a rapid and continuous learning health system requires socio-technical harmonization of research and operational IT.

Cong Liu, Casey N Ta, Elisabeth S DiMaria, Rachel C Shelton, Karthik Natarajan, Soumitra Sengupta, James J Cimino, Chunhua Weng

Abstract readReview
In one paragraph

Review in npj health systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cong LiuDepartment of Pediatrics, Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02445 USA.
Casey N TaDepartment of Biomedical Informatics, Columbia University, New York, NY 10032 USA.
Elisabeth S DiMariaIrving Institute for Clinical and Translational Research, Columbia University, New York, NY 10032 USA.
Rachel C SheltonImplementation Science Initiative, Columbia University, New York, NY 10032 USA.
Karthik NatarajanDepartment of Biomedical Informatics, Columbia University, New York, NY 10032 USA.
Soumitra SenguptaDepartment of Biomedical Informatics, Columbia University, New York, NY 10032 USA.
James J CiminoDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, AL 35233 USA.
Chunhua WengDepartment of Biomedical Informatics, Columbia University, New York, NY 10032 USA.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
RESCUE: Rare Disease Detection and Escalation Support via a Learning Health SystemR01HG012655 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Cong Liu · 2022 to 2026
$4.1M
Fair Phenotype Annotation and Genomic ReinterpretationR01HG013031 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, CHUNHUA WENG · 2023 to 2026
$3.5M
Deep phenotyping in Electronic Health Records for Genomic MedicineR01LM012895 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, KAI, WENG, CHUNHUA · 2018 to 2021
$3.3M
Deep learning based predictive analytics to improve patient health.R01LM013061 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk, CHUNHUA WENG · 2019 to 2026
$2.7M
NCATS NIH HHS UL1 TR001873NHGRI NIH HHS R01 HG012655NHGRI NIH HHS R01 HG013031NHGRI NIH HHS U01 HG008680NLM NIH HHS R01 LM012895NLM NIH HHS R01 LM013061
6 · The paper itself

Abstract

This perspective identifies challenges in integrating clinical research and care delivery in a rapid and continuous Learning Health System (LHS), focusing on Information technology (IT) systems and workforce harmonization. Based on our experiences, we analyzed differences in funding mechanisms, governance, regulatory frameworks, priorities, workforce culture, technology architecture, risk tolerance, and data standardization. We highlight significant barriers to the LHS implementation caused by IT misalignment between clinical research and patient care and propose strategies to overcome these challenges.

Indexed as

Hardware and infrastructureStandardsTranslational research

Identifiers

PMID40860316
PMCPMC12370530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.