Evidence map›Paper›PMID 40860257›Full record

ArticleiScience2025

Blood immunomap for prediction of responses to anti-PD-1 immunotherapy in metastatic non-small cell lung cancer.

Maria Semitekolou, Nikolaos Paschalidis, Domenico Lo Tartaro, Aikaterini Tsitsopoulou, Panagiota Stamou, Alexandros Mavroudis, Effrosyni Markaki, Athina Varveri, Ioannis Morianos, Matthieu Lavigne and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Maria SemitekolouLaboratory of Immune Regulation and Tolerance, Division of Basic Sciences, Medical School, University of Crete, 70013 Heraklion, Greece.
Nikolaos PaschalidisBiomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
Domenico Lo TartaroDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, 41121 Modena, Italy.
Aikaterini TsitsopoulouBiomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
Panagiota StamouLaboratory of Immune Regulation and Tolerance, Division of Basic Sciences, Medical School, University of Crete, 70013 Heraklion, Greece.
Alexandros MavroudisLaboratory of Immune Regulation and Tolerance, Division of Basic Sciences, Medical School, University of Crete, 70013 Heraklion, Greece.
Effrosyni MarkakiLaboratory of Immune Regulation and Tolerance, Division of Basic Sciences, Medical School, University of Crete, 70013 Heraklion, Greece.
Athina VarveriLaboratory of Immune Regulation and Tolerance, Division of Basic Sciences, Medical School, University of Crete, 70013 Heraklion, Greece.
Ioannis MorianosHost Defense & Fungal Pathogenesis Laboratory, Medical School, University of Crete, 70013 Heraklion, Greece.
Matthieu LavigneInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology - Hellas (FORTH), 70013 Heraklion, Greece.
Charalampos FotsitzoudisLaboratory of Translational Oncology, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Sofia MagkoutaDepartment of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantina DedeDepartment of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Ioannis KalomenidisDepartment of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantinos SamitasRespiratory Clinic and Asthma Center of the 'Sotiria' Athens Chest Hospital, Athens, Greece.
Konstantinos PotarisDepartment of Thoracic Surgery, Athens Chest Hospital 'Sotiria', 11527 Athens, Greece.
Andrea CossarizzaDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, 41121 Modena, Italy.
Dimitrios MavroudisLaboratory of Translational Oncology, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Sara De BiasiDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, 41121 Modena, Italy.
Panayiotis VerginisLaboratory of Immune Regulation and Tolerance, Division of Basic Sciences, Medical School, University of Crete, 70013 Heraklion, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification of circulating predictors of response to ICB therapy is vital as very few of them meet the demands of the clinic. Herein, by using high-dimensionality mass cytometry, we designed a blood immunomap in metastatic NSCLC individuals who underwent anti-PD-1 treatment. We identified heightened frequencies of CD8

Indexed as

CancerTranscriptomics

Identifiers

PMID40860257
PMCPMC12375241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.