ArticleFrontiers in ophthalmology2025
Damage processes in extended laser exposures using an
Article in Frontiers in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- QUILPEN Provides Independent and Label-Free Single-Cell Quantification of Pigmentation Dynamics and Organelle Content.Pigment cell & melanoma research · 2026Article
- Unified modeling of photothermal and photochemical damage.Frontiers in ophthalmology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal pigment epithelial (RPE) cells are sensitive to both photothermal and photochemical damage when exposed to lasers with wavelengths associated with the retinal blue light hazard. Laser power density (irradiance) and exposure duration primarily dictate the damage mechanism. Relatively high irradiances and short exposure durations typically lead to melanin-dependent photothermal damage, whereas low irradiance and long duration exposures are required for photochemical pathways. However, little is known about damage mechanisms at intermediate irradiances and durations for pigmented cells. The current Z136.1-2022 laser safety standard from the American National Standards Institute (ANSI) does not consider combined photothermal and photochemical damage processes. In addition, the ANSI Z136.1 standard classifies photochemical damage as nonthermal. Here, we use extended laser exposure parameters in an
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Registered trials
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