Evidence map›Paper›PMID 40860160›Full record

ArticleTheranostics2025

CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription.

Mengdi Li, Yuting Lin, Jiayu Wang, He Yang, Danhui Ma, Ye Tian, Yi Wang, Liu Yang, Umar Farooq, Yinyin Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mengdi LiState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Yuting LinState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Jiayu WangState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
He YangState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Danhui MaState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Ye TianBeijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
Yi WangKey Laboratory of Industrial Biocatalysis, Ministry of Education of China, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
Liu YangState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Umar FarooqJinfeng Laboratory, Chongqing, 401329, China.
Yinyin WangState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Fangli RenState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Jian ShengDepartment of science and education department, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, China.
Guoqing ZhangThoracic Surgery Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Liang ChenInstitute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Jun LiHeya Pharmaceutical Technology Company, Beijing, 100176, China.
Xiangnan LiThoracic Surgery Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhijie ChangState Key Laboratory of Membrane Biology, School of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenocarcinoma of LungCyclin-Dependent Kinase 9Lung NeoplasmsRNA Polymerase IIAnimalsCell Line, TumorDisease ProgressionErbB ReceptorsGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemMiceProto-Oncogene Proteins p21(ras)Transcription, GeneticCDK9 protein, humanCyclin-Dependent Kinase 9ErbB ReceptorsKRAS protein, humanProto-Oncogene Proteins p21(ras)RNA Polymerase IICell cycle-related and expression elevated protein in tumor (CREPT)Cyclin-dependent kinase 9 (CDK9)Extracellular signal-regulated kinase (ERK)Kirsten rat sarcoma proto-oncogene (KRAS)Lung adenocarcinoma (LUAD)

Identifiers

PMID40860160
PMCPMC12374588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.