Evidence map›Paper›PMID 40860085›Full record

ArticleRSC advances2025

Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study.

Reda R Mabrouk, Arafa Musa, Maged Mohammed Saleh Al Ward, Shaimaa Hussein, Ahmed K B Aljohani, Mohamed Ayman El-Zahabi, Alaa Elwan

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Reda R MabroukPharmaceutical Medicinal Chemistry& Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt alaaelwan34@azhar.edu.eg malzahaby@azhar.edu.eg.
Arafa MusaDepartment of Pharmacognosy, College of Pharmacy, Jouf University Sakaka Aljouf 72341 Saudi Arabia akmusa@ju.edu.sa.
Maged Mohammed Saleh Al WardPharmaceutical Medicinal Chemistry& Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt alaaelwan34@azhar.edu.eg malzahaby@azhar.edu.eg.
Shaimaa HusseinDepartment of Pharmacology, College of Pharmacy, Jouf University Sakaka Aljouf 72341 Saudi Arabia.ORCID https://orcid.org/0000-0003-0998-482X
Ahmed K B AljohaniPharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University Medina Saudi Arabia.
Mohamed Ayman El-ZahabiPharmaceutical Medicinal Chemistry& Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt alaaelwan34@azhar.edu.eg malzahaby@azhar.edu.eg.
Alaa ElwanPharmaceutical Medicinal Chemistry& Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt alaaelwan34@azhar.edu.eg malzahaby@azhar.edu.eg.ORCID https://orcid.org/0000-0003-4270-616X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of quinazoline-based compounds were designed and synthesized as modified analogues to certain known VEGFR-2 inhibitors, as an extension of our work on the design and synthesis of new VEGFR-2 inhibitors. The anti-proliferative properties of the synthesized compounds were assessed

Identifiers

PMID40860085
PMCPMC12377202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.