ArticleJournal of pharmacy & bioallied sciences
A Prospective Observational Study in Adult Medical Intensive Care Unit Patients with Drug-Induced QTc with Correlation of Serum Potassium, Magnesium Level of Clinical Outcome.
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Experience of a Single-Center Voriconazole TDM Bioassay for Hospitalized Patients with Invasive Fungal Infections.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Drug-induced QTc prolongation is a significant concern in critically ill patients, increasing the risk of life-threatening arrhythmias. This prospective observational study evaluates the association between QTc prolongation, serum potassium and magnesium levels, and clinical outcomes in adult medical intensive care unit (ICU) patients. Methodology: The study included 116 adult ICU patients prescribed QTc-prolonging drugs, excluding those with atrial fibrillation, pacemakers, or early transfers. Electrocardiograms (ECG) and serum electrolyte levels were analyzed to assess QTc prolongation and its correlation with arrhythmias, ICU stay, and mortality. The Tisdale risk score categorized patients into low, medium, and high-risk groups. Results: QTc prolongation occurred in 29 patients, with males showing a higher incidence. Common diagnoses included sepsis, myocardial infarction, and coronary artery disease. Drugs frequently implicated were ondansetron (17.24%), fluconazole (10.34%), and amiodarone (6.89%). Among these, 11 patients were high-risk, 12 moderate-risk, and 6 low-risk. Significant changes were noted in ECG and potassium levels, but not in magnesium, chloride, or creatinine. Conclusion: This study highlights the importance of monitoring and managing QTc-prolonging medications and associated risk factors, such as serum potassium and magnesium levels, to reduce arrhythmia risk and improve ICU outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.