Evidence map›Paper›PMID 40859981›Full record

ArticleJournal of cell communication and signaling2025

CD2-CD58 axis orchestrates cytotoxic T lymphocyte function and metabolic crosstalk in breast cancer brain metastasis.

Guanyou Huang, Yigong Wei, Xiaohong Hou, Xin Jia, Yong Yu, Xu Li, Shanshan Yu

Abstract read
In one paragraph

Article in Journal of cell communication and signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guanyou HuangDepartment of Neurosurgery The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.ORCID https://orcid.org/0000-0001-5609-1712
Yigong WeiDepartment of Neurosurgery The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.
Xiaohong HouDepartment of Neurosurgery The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.
Xin JiaDepartment of Neurosurgery The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.
Yong YuDepartment of Neurosurgery The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.
Xu LiDepartment of Oncology The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.
Shanshan YuDepartment of Neurocritical Care The Second People's Hospital of Guiyang (Jinyang Hospital) Guiyang China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the impact of the CD2-CD58 signaling axis on effector T cell function and tumor metabolic crosstalk in breast cancer brain metastasis (BCBM) using single-cell transcriptomic analysis. scRNA-seq data analysis revealed the critical role of CD2-CD58 signaling between CD8

Indexed as

breast cancer brain metastasisCD2‐CD58 axisCD8+ Effector T cellimmunometabolic crosstalksingle‐cell transcriptomicstumor metabolic reprogramming

Identifiers

PMID40859981
PMCPMC12375503

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.