ArticleDrug design, development and therapy2025
Effects of Different Application Routes of Ozone on Testicular Tissue in Rats with Spinal Cord Ischemia and Reperfusion Injury.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury.World journal of experimental medicine · 2026Article
- Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorates Testicular injury to improve spermatogenic disorder through PRDX1/TRAF6/TGFβ signaling pathway.Clinical and experimental medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Spinal cord ischemia-reperfusion injury (IRI) is a serious condition that can develop after spinal and thoracoabdominal surgeries or spinal cord traumas. The aim of this study was to investigate the effects of different administration routes of ozone on testicular tissue in rats with spinal cord ischemia and reperfusion injury. Methods: Rats were divided into five groups (n:5): control (C), ischemia-reperfusion (IR), IR-rectal ozone (IR+RO), IR-intratechal ozone (IR+ITO), and IR-intraperitoneal (i.p) ozone (IR+IPO). Ozone-oxygen mixture was administered 30 minutes before midline laparotomy: 1 mg/kg (50 µg/mL) by rectal insufflation to the IR+RO group, 20 µL (20 µg/mL) intratechally to the IR+ITO group, and 0.7 µg/kg (50 µg/mL) intraperitoneally to the IR+IPO group. The spinal cord IR model was established. The testicular tissue was collected for histopathological and biochemical analyses. Results: The Malondialdehyde (MDA) levels and Paraoxonase-1 (PON1) activities were significantly lower in the IR+RO, IR+ITO, and IR+IPO groups than in the IR group. Catalase (CAT) was significantly higher in the IR+ITO and IR+IPO groups than in the IR group. While the Cosentino score was significantly higher in the IR group than in the C group (p<0.001), it was significantly lower in the IR+RO, IR+ITO and IR+IPO groups than in the IR group (p<0.001, all). Conclusion: Ozone can regulate the negative effects of IRI by regulating cellular oxidative stress mechanisms. This effect can be achieved most effectively on testis tissue in the spinal cord IRI model through intrathecal and intraperitoneal administration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.