Evidence map›Paper›PMID 40859954›Full record

ArticleInternational journal of nanomedicine2025

A Novel Integrated Approach: Plant-Mediated Synthesis, in vitro and in silico Evaluation of Silver Nanoparticles for Breast Cancer and Bacterial Therapies.

Sahar S Alghamdi, Haifa A Alhaidal, Afrah E Mohammed, Arwa Alsubait, Maali D Alshammari, Lamis Alsaqer, Shahad Saleem Alzahrani, Fai Alanazi, Layan Basel Al Tuhayni, Rizwan Ali and 4 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Green-synthesizedRSC advances · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sahar S AlghamdiCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Haifa A AlhaidalCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Afrah E MohammedDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University (PNU), Riyadh, 11671, Saudi Arabia.
Arwa AlsubaitMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
Maali D AlshammariDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Lamis AlsaqerCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Shahad Saleem AlzahraniCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Fai AlanaziCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Layan Basel Al TuhayniCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Rizwan AliMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.ORCID 0000-0002-2475-0258
Shaden AlharbiCollege of Pharmacy (COP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Bader HazaziMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.ORCID 0000-0003-4886-6578
Mona E AlEnaziDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Zeyad I AlehaidebMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.ORCID 0000-0002-7185-2820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Nanotechnology offers a promising approach to address breast cancer and bacterial resistance, two critical global health challenges. This study synthesized silver nanoparticles (AgNPs) using extracts from Materials and Methods: AgNP synthesis was achieved via co-precipitation, and their characterization was performed using various techniques. Cytotoxicity was assessed using the MTT assay against multiple breast cancer cell lines (KAIMRC2, MDA-MB231, MCF-7) and a non-malignant control (MCF-10A). Antimicrobial activity was evaluated using a well diffusion assay against Results: The resulting AgNPs demonstrated significant cytotoxicity against breast cancer cells with minimal toxicity to normal cells, and potent antibacterial activity. Specifically, Conclusion: Further research focusing on the optimization and preclinical development of these identified metabolites is warranted to explore their translational potential as oral anti-cancer and antibacterial agents.

Indexed as

Anti-Bacterial AgentsBreast NeoplasmsMetal NanoparticlesPlant ExtractsSilverAntineoplastic AgentsCell Line, TumorCell SurvivalComputer SimulationEscherichia coliFemaleHumansMCF-7 CellsMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsAntineoplastic AgentsPlant ExtractsSilveranti-cancerbactericidalCalligonum comosumCalotropis procerananomedicineRhazya stricta

Identifiers

PMID40859954
PMCPMC12374718

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.