Evidence map›Paper›PMID 40859932›Full record

ArticleACS chemical neuroscience2025

Modulation of Amyloid-β Aggregation by Surface Proteins from Pathogens Associated with Alzheimer's Disease.

Antonin Kunka, Hana Hribkova, Tereza Vanova, Veronika Pospisilova, Martin Havlasek, Jan Haviernik, Daniel Ruzek, Jiri Damborsky, Dasa Bohaciakova, Zbynek Prokop

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antonin KunkaLoschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.
Hana HribkovaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Tereza VanovaInternational Clinical Research Center, St. Anne's University Hospital Brno, Brno 602 00, Czech Republic.
Veronika PospisilovaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Martin HavlasekLoschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.
Jan HaviernikVeterinary Research Institute, Brno 621 00, Czech Republic.
Daniel RuzekVeterinary Research Institute, Brno 621 00, Czech Republic.ORCID 0000-0003-4655-2380
Jiri DamborskyLoschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.ORCID 0000-0002-7848-8216
Dasa BohaciakovaInternational Clinical Research Center, St. Anne's University Hospital Brno, Brno 602 00, Czech Republic.
Zbynek ProkopLoschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.ORCID 0000-0001-9358-4081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder. Despite substantial research efforts, our understanding of its pathogenesis remains incomplete, limiting the development of effective treatments and preventive strategies. The potential role of microbial pathogens in AD etiology has gained increasing attention. Various human microbial pathogens have been identified in the brains of AD patients, leading to the pathogen hypothesis, which posits that these microorganisms may disrupt the brain's immune regulation and homeostasis. In this study, we examine the effects of proteins from three pathogens,

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBacterial ProteinsPeptide FragmentsAmyloid beta-Protein PrecursorBorrelia burgdorferiHerpesvirus 1, HumanHumansNeuronsPorphyromonas gingivalisAmyloid beta-Peptidesamyloid beta-protein (1-42)Amyloid beta-Protein PrecursorBacterial ProteinsPeptide FragmentsAlzheimer’s diseaseamyloidsamyloid-βneuroinflammationpathogenvirus

Identifiers

PMID40859932
PMCPMC12447514

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.