Evidence map›Paper›PMID 40859928›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Biocompatible Mesoporous Materials for Bone Therapy.

Biao Yu, Yan Wu, Yang Hong, Peng Wang, Xiaowen Liu, Yonghui Deng, Jiacan Su

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Biocompatible Mesoporous Materials for Bone Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Biao YuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, P. R. China.
Yan WuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, P. R. China.
Yang HongInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, P. R. China.
Peng WangDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, P. R. China.
Xiaowen LiuDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Coatings for Advanced Equipment, iChEM, Fudan University, Shanghai, 200433, P. R. China.
Yonghui DengDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Coatings for Advanced Equipment, iChEM, Fudan University, Shanghai, 200433, P. R. China.ORCID https://orcid.org/0000-0002-0657-9397
Jiacan SuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, P. R. China.

Funding

Innovation Fund of Shanghai University Graduate College for Engineers 2025GCE3-15National Natural Science Foundation of China 82230071,82172098PostGraduate Innovation Fund of Interdiscipline and New Medicine from School of Medicine of Shanghai UniversityScience and Technology Commission of Shanghai Municipality 2024ZDSYS02Shanghai Committee of Science and Technology Laboratory Animal Research Project 23141900600Shanghai Innovative Medical Device Application Project 23SHS05700
6 · The paper itself

Abstract

As global population aging intensifies, bone-related diseases have become a significant public health challenge, necessitating the development of efficient and precise bone repair strategies. Biocompatible mesoporous materials (BMMs), characterized by their high specific surface area, tunable pore size, multidimensional functionalization potential, and excellent biocompatibility, have demonstrated revolutionary application prospects in treating bone-related diseases. This review systematically summarizes the latest research progress and application mechanisms of BMMs (e.g., mesoporous silica, mesoporous bioactive glass) in bone-related diseases. It also thoroughly discusses the synthesis methods and functionalization strategies of BMMs, including designs for biocompatibility and biodegradability, targeting capabilities, bio-responsiveness, and regulation of cellular behavior. The article emphasizes and analyzes the preclinical research applications of BMMs in bone-targeted drug delivery, bone tissue engineering, bone implant coatings, and integrated diagnosis and therapy. Finally, it provides a retrospective analysis and future perspectives on the application of BMMs in bone-related diseases, aiming to promote a transition from fragmented breakthroughs to systematic development in BMMs research. This effort seeks to provide a scientific framework for optimizing material design and advancing clinical applications.

Indexed as

Biocompatible MaterialsBone and BonesBone DiseasesTissue EngineeringAnimalsHumansPorosityBiocompatible Materialsbone regenerationbone repairbone therapydrug delivery systemmesoporous materials

Identifiers

PMID40859928
PMCPMC12533334

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.