Evidence map›Paper›PMID 40859863›Full record

ArticleMovement disorders clinical practice2026

Thalamic Deep Brain Stimulation for Dystonic Head Tremor: A Long-Term Study of 18 Patients.

Johanna M Nagel, Marc E Wolf, Christian Blahak, Joachim Runge, Christoph Schrader, Dirk Dressler, Assel Saryyeva, Joachim K Krauss

Abstract read
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Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Johanna M NagelDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0009-0007-5082-0460
Marc E WolfDepartment of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.ORCID https://orcid.org/0000-0002-7683-6918
Christian BlahakDepartment of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.
Joachim RungeDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.
Christoph SchraderDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Dirk DresslerDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Assel SaryyevaDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.
Joachim K KraussDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-0675-9064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDystonic head tremor is a particular manifestation of dystonia, which is difficult to treat. Although deep brain stimulation (DBS) of the globus pallidus internus has been established as a treatment for different phenotypes of dystonia, its role in dystonic tremor has been debated. Although thalamic targets have been used for treatment of dystonic tremor of the extremities, there is limited experience with dystonic head tremor.

objectivesHere, we present our experience with thalamic ventral intermediate (Vim) nucleus DBS in a consecutive series of patients providing long-term follow-up.

methodsEighteen patients with dystonic head tremor as the leading symptom underwent the implantation of quadripolar DBS electrodes into the thalamic Vim. Patients' symptoms were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale motor (BFMDRS-M) and disability (BFMDRS-D) scores, and a modified Fahn-Tolosa-Marin Tremor Rating Scale (mFTMTRS), preoperatively, at short-term (3 months-2 years), and at long-term follow-up (>2 years).

resultsThere was improvement in both tremor and dystonia rating scales. Tremor scores were reduced from a value of 7.94 preoperatively to 2.0 at short term (P < 0.001) and to 1.71 at long-term follow-up (P < 0.001). BFMDRS-M scores were reduced from 14.56 to 7.8 (P < 0.001) and to 7.0 (P < 0.001), and BFMDRS-D scores from 3.88 to 2.65 (P < 0.05) and to 2.71 (P < 0.05), respectively, during chronic stimulation.

conclusionsOur results indicate that Vim DBS is a safe and efficient treatment option for dystonic head tremor with stable long-term results. We suggest Vim DBS as an alternative to pallidal DBS in cases where head tremor is the leading symptom.

Indexed as

Deep Brain StimulationDystoniaDystonic DisordersThalamusTremorVentral Thalamic NucleiAdultAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedTreatment Outcomecervical dystoniadeep brain stimulationdystoniahead tremorthalamusventral intermediate nucleus

Identifiers

PMID40859863
PMCPMC12999030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.