Evidence map›Paper›PMID 40859824›Full record

ArticleCirculation research2025

RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing.

Tongbin Wu, Zeyu Chen, Chao Gao, Elise V Stanley, Zengming Zhang, Yusu Gu, Xiaohai Zhou, Ju Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Elucidating Gene Functions in Congenital Heart Disease.Current treatment options in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Tongbin Wu *Department of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (T.W., C.G., E.V.S.).ORCID 0000-0001-6232-3268
Zeyu Chen *Department of Medicine, University of California San Diego, La Jolla, CA (Z.C., Z.Z., Y.G., X.Z., J.C.).ORCID 0000-0003-3442-4162
Chao GaoDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (T.W., C.G., E.V.S.).ORCID 0000-0001-6939-9345
Elise V StanleyDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (T.W., C.G., E.V.S.).
Zengming ZhangDepartment of Medicine, University of California San Diego, La Jolla, CA (Z.C., Z.Z., Y.G., X.Z., J.C.).
Yusu GuDepartment of Medicine, University of California San Diego, La Jolla, CA (Z.C., Z.Z., Y.G., X.Z., J.C.).ORCID 0000-0002-9543-8472
Xiaohai ZhouDepartment of Medicine, University of California San Diego, La Jolla, CA (Z.C., Z.Z., Y.G., X.Z., J.C.).ORCID 0000-0002-0987-0374
Ju ChenDepartment of Medicine, University of California San Diego, La Jolla, CA (Z.C., Z.Z., Y.G., X.Z., J.C.).ORCID 0000-0001-7674-4776

Funding

ATF4 a Novel Regulator of Cardiac DevelopmentR01HL164549 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen · 2023 to 2026
$2.2M
Molecular basis of ASNA1 cardiomyopathyR01HL170002 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen · 2024 to 2026
$1.6M
Gene Therapy for ALPK3 Cardiomyopathy Using MiniALPK3R01HL175344 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen · 2024 to 2026
$1.6M
PRDM16 in cardiac developmentR01HL153032 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL153032NHLBI NIH HHS R01 HL164549NHLBI NIH HHS R01 HL170002NHLBI NIH HHS R01 HL175344
6 · The paper itself

Abstract

backgroundMutations in cardiac SFs (splicing factors) cause cardiomyopathy and congenital heart disease, underscoring the critical role of SFs in cardiac development and disease. Cardiac SFs are implicated to cooperatively regulate the splicing of essential cardiac genes, but the functional importance of their collaboration remains unclear. RBPMS (RNA-binding protein with multiple splicing) and RBPMS2 (RNA-binding protein with multiple splicing 2) are SFs involved in heart development and exhibit similar splicing regulatory activities in vitro, but it is unknown whether they cooperate to regulate splicing in vivo.

methods

resultsMice lacking both RBPMS and RBPMS2 in cardiomyocytes died before embryonic day 13.5 and developed sarcomere disarray, whereas

conclusionsOur results demonstrate that RBPMS and RBPMS2 work in concert to safeguard the splicing of genes essential for cardiac contraction, highlighting the importance of SF collaboration in maintaining cardiac splicing signature, which should be taken into consideration when devising future therapeutic approaches through modulating the activity of SFs.

Indexed as

Myocytes, CardiacRNA-Binding ProteinsRNA SplicingRNA Splicing FactorsAnimalsHeartMiceMice, KnockoutSarcomeresRNA-Binding ProteinsRNA Splicing Factorsalternative splicingcardiomyopathiesmyocytes, cardiacRNA splicingRNA splicing factorssarcomeres

Identifiers

PMID40859824
PMCPMC12744351

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.