ArticleJournal of veterinary internal medicine
Extended Survival in a Dog With Disseminated Protothecosis.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Successful treatment of the first reported case of Prototheca wickerhamii infection in a dog living in Tasmania, Australia.Australian veterinary journal · 2026Article
- Extended Survival in a Dog With Disseminated Protothecosis.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 5-year-old Basenji Mix achieved extended survival with treatment for disseminated protothecosis. The dog originally presented with iridal hyperemia and ocular ultrasonographic examination revealed a mass effect. Histopathology revealed ocular protothecosis and staging confirmed disseminated protothecosis. Treatment with itraconazole and amphotericin B (AmB) infusions resulted in remission. Four years later, restaging revealed recurrence of infection in colonic biopsy samples. An extended AmB protocol was restarted for a cumulative dose of 84 mg/kg and the dog received isavuconazole based on susceptibility testing. The dog was euthanized 4 years and 8 months after initial diagnosis due to decline of neurologic status. Necropsy confirmed the presence of disseminated protothecosis in multiple arteries, multiple lymph nodes, the pituitary gland, thyroid glands, kidneys, colon, cecum, right eyelid, right eye, heart, brain, and periosteum of one bone associated with the middle ear. This report documents the extended survival of a dog with widespread disseminated protothecosis after prolonged administration of AmB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.