Evidence map›Paper›PMID 40859683›Full record

ArticleHuman vaccines & immunotherapeutics2025

Association between depression and three key COVID-19-related outcomes: The SHARE study.

Yumeng Gao, Chunxiao Duan, Tongtong Miao, Qian Shen, Jia Yu, Suwen Shen, Yujun Chen, Yuan Shen, Kaixin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yumeng GaoDepartment of Acute Infectious Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China.
Chunxiao DuanDepartment of Acute Infectious Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China.
Tongtong MiaoDepartment of Pharmacy, Nantong First People's Hospital, Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Qian ShenDepartment of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China.
Jia YuDepartment of Acute Infectious Disease Control and Immunization Program, Wuzhong Center for Disease Control and Prevention, Suzhou, Jiangsu, China.
Suwen ShenDepartment of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China.
Yujun ChenDepartment of Acute Infectious Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China.
Yuan ShenDepartment of Acute Infectious Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China.ORCID 0000-0002-6845-467X
Kaixin ZhangDepartment of Clinical Research Center, Jiangnan University Medical Center, Wuxi, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the potential associations between preexisting depression and COVID-19 vaccination, SARS-CoV-2 infection risk, and long COVID among middle-aged and older Europeans, based on the Survey of Health, Ageing and Retirement in Europe (SHARE). A total of 31,115 participants were included to assess the relationship between depression and COVID-19 vaccination 11,146 to evaluate depression-related SARS-CoV-2 infection risk, and 11,142 to study the impact of depression on the occurrence of long COVID. Multivariable logistic model was performed and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Compared to non-depressed individuals, those with depression were 0.72 times less likely to receive the COVID-19 vaccine (95% CI: 0.67-0.77), had a 1.15 times higher risk of SARS-CoV-2 infection (95% CI: 1.02-1.30), and were 1.21 times more likely to develop long COVID (95% CI: 1.05-1.38), with these associations strengthening as the severity of depression increased. Preexisting depression might be linked to reduced COVID-19 vaccination odds and an elevated risk of SARS-CoV-2 infection and long COVID, although further high-quality prospective studies with larger samples are needed to confirm the findings.

Indexed as

COVID-19COVID-19 VaccinesDepressionAgedEuropeFemaleHumansMaleMiddle AgedRisk FactorsSARS-CoV-2VaccinationCOVID-19 VaccinesCOVID-19 vaccinationDepressionepidemiological researchlong COVIDSARS-CoV-2 infectionsurvey of health, ageing, and retirement in Europe

Identifiers

PMID40859683
PMCPMC12392796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.