Evidence map›Paper›PMID 40859629›Full record

ArticleJournal of veterinary internal medicine

Cholesterol Ester Storage Disease in Two Field Spaniels With Lysosomal Acid Lipase Deficiency.

Pernilla Syrjä, Mathilda M H Ylenius, Matilda Kråkström, Alex M Dickens, Elina Rautala, Anna Huupponen, Anders Eriksson, Sanna J Viitanen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pernilla SyrjäDepartment of Veterinary Biosciences, Section for Veterinary Pathology and Parasitology, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Mathilda M H YleniusDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Matilda KråkströmTurku Bioscience Centre, University of Turku, Turku, Finland.
Alex M DickensTurku Bioscience Centre, University of Turku, Turku, Finland.
Elina RautalaDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-1769-7559
Anna HuupponenDepartment of Veterinary Biosciences, Section for Veterinary Pathology and Parasitology, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Anders ErikssonCarditech, Espoo, Finland.
Sanna J ViitanenDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-1208-5799

Funding

University of Helsinki Fund for Veterinary Medicine/Fund for Research in Canine Health
6 · The paper itself

Abstract

Cholesterol ester storage disease (CESD) is a rare genetic lysosomal storage disorder resulting from lower lysosomal acid lipase (LAL) activity. LAL is an essential enzyme required in intracellular lipid metabolism, and deficiency results in disability to properly break down and utilize lipids and in the accumulation of especially cholesterol esters in many organs such as the liver, spleen, and bone marrow. This case report describes clinical findings, LAL activity measurement, blood and liver tissue lipidomic changes, as well as pathological findings in two unrelated Field Spaniels with LAL deficiency and CESD.

Indexed as

Cholesterol Ester Storage DiseaseDog DiseasesSterol EsteraseWolman DiseaseAnimalsDogsLiverSterol Esterasecaninedoglipid metabolismlipidomic

Identifiers

PMID40859629
PMCPMC12380722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.