Evidence map›Paper›PMID 40859605›Full record

ArticleVeterinary medicine and science2025

Intralipid emulsion therapy for ivermectin toxicity in a dog.

Ehsan Khaksar, Hamed Karimi, Mahdieh Rezaei, Salar Zehforosh

Abstract readCase Reports
In one paragraph

Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ehsan KhaksarDepartment of Veterinary Clinical Science, G.C Islamic Azad University, Garmsar, Iran.ORCID https://orcid.org/0000-0001-7363-0300
Hamed KarimiDepartment of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.ORCID https://orcid.org/0009-0003-9164-8434
Mahdieh RezaeiDepartment of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.ORCID https://orcid.org/0000-0003-0783-4123
Salar ZehforoshDepartment of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.ORCID https://orcid.org/0009-0005-4412-8465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTherapeutic management of ivermectin overdose in a Shih Tzu dog using intravenous administration of intravenous lipid emulsion (ILE). CASE SUMMARY: A 3-year-old female Shih Tzu dog weighing 2.5 kg was presented to a veterinary clinic in Tehran with ataxia, tremors, incoordination, negative PLR and menace reflex, bradycardia and salivation. The patient was treated with a 10 mg ivermectin tablet with the brand name Medimect in the last 12 h. Following the diagnosis of ivermectin intoxication, treatment with ILE was initiated. ILE was administered as a bolus of 1.5 mL/kg in 1 min, followed by a dose of 0.25 mL/kg/min for 30 min as a CRI. The neurological symptoms of the patient began to decrease 2.5 h after the ILE therapy. Twenty-four hours later, the patient was resuscitated, and all symptoms were resolved.

conclusionThe current paper reports the successful treatment of ivermectin toxicity with ILE therapy in Iran. The education of veterinarians regarding the beneficial and varied roles of ILE therapy in different clinical settings is warranted, particularly in terms of the potential for ILE therapy to reverse the toxicities of various lipophilic drugs.

Indexed as

Antiparasitic AgentsDog DiseasesDrug OverdoseFat Emulsions, IntravenousIvermectinAnimalsDogsFemaleIranAntiparasitic AgentsFat Emulsions, IntravenousIvermectindogintralipidivermectintoxicity

Identifiers

PMID40859605
PMCPMC12380713

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.