SynthesisMedicine2025
Acupuncture monotherapy for endometriosis-related pain: A systematic review and meta-analysis.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Emerging Non-Pharmacological Approaches in Endometriosis: Mechanistic Insights into Phototherapy, Hyperthermia, and Acupuncture-Literature Review.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluated the efficacy of acupuncture as a monotherapy for managing endometriosis-related pain (ERP) compared to non-acupuncture interventions.
methodsWe systematically searched PubMed, EMBASE, Cochrane Library, CNKI, WANGFANG, and VIP databases from inception to March 1, 2025, for randomized controlled trials (RCTs) comparing acupuncture alone with non-acupuncture treatments in ERP patients. Included trials were assessed for methodological quality using the Cochrane risk-of-bias tool, and statistical analyses by RevMan 5.4.
resultsNine RCTs involving 535 patients were included. Meta-analysis revealed that acupuncture significantly reduced pain intensity, as measured by the visual analog scale (mean difference = -1.67, 95% confidence interval [CI]: -2.85 to -0.49, P = .006) and improved clinical response rates (odds ratio = 2.61, 95% CI: 1.38-4.95, P = .003). However, no significant differences were observed in serum CA125 levels (mean difference = -1.46, 95% CI: -20.69 to 17.76, P = .88) or overall effective rate (odds ratio = 2.18, 95% CI: 0.99-4.80, P = .05).
conclusionAcupuncture may serve as an effective standalone therapy for ERP, particularly in pain relief and clinical response. However, due to heterogeneity and methodological limitations in the included studies, further large-scale, high-quality RCTs are warranted to validate these findings and establish long-term efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.