ArticleAlimentary pharmacology & therapeutics2026
Telemetric Assessment and Comparison of Regional Colonic Metabolic Activity in Ambulant Healthy Individuals Using pH and Gas-Sensing Wireless Motility Capsules.
Article in Alimentary pharmacology & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Critical Review: The Past, Present, and Future of Small Intestinal Bacterial Overgrowth (SIBO).JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- Microenvironment-Responsive Nanomaterials for Colorectal Anastomotic Healing: A Signal-Threshold-Response Framework for Stage-Adaptive Repair.International journal of nanomedicine · 2026Review
- Patient-centered gastrointestinal function assessment technologies: a paradigm shift from traditional approaches to non-invasive innovations.Frontiers in physiology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundIngestible wireless motility capsules enable locoregional quantification of luminal pH and concentrations of hydrogen and carbon dioxide in the human colon.
aimTo evaluate these measures in the colon of healthy adults.
methodsGas-sensing and pH-sensing wireless motility capsules were ingested tandemly and repeatedly over time. Measurements were analysed and compared in proximal and distal segments of the colon.
resultsIn paired datasets from 37 participants, colonic pH rose from a median 6.3 (IQR 5.8-6.9) proximally to 7.0 (6.6-7.2) distally (p < 0.001). Concentrations of carbon dioxide rose in nearly all participants from 12.7 (9.1-18.6) proximally to 18.8 (11.9-28.1) %.h/h distally (p < 0.001) with a positive correlation between proximal and distal colon (r = 0.76; p < 0.001). Hydrogen concentrations showed widely varied proximal-to-distal gradients with an increase in 69% of participants, but no correlation between proximal and distal colon measures. No significant correlations between colonic pH, hydrogen concentrations, and carbon dioxide concentrations were observed. Comparison of hydrogen and carbon dioxide concentrations between tandem gas-sensing capsules by Bland-Altman analysis (n = 24) showed minimal (< 1.2%) bias for both measures, and gas metrics on repeat ingestion were similar (n = 20). However, there was greater variance in the distal colon.
conclusionsBoth wireless motility capsules evaluate different yet complementary aspects of colonic fermentation. Carbon dioxide concentrations that most likely reflect overall microbial metabolic activity were consistently greater distally, while proximal-to-distal gradients in hydrogen concentrations varied, likely due to inter-subject variations in dietary carbohydrate and/or methanogenesis. Luminal pH poorly reflects carbohydrate fermentation in the distal colon.
trial registrationACTRN12619001219178 and ACTRN12622000422729.
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Registered trials
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