Evidence map›Paper›PMID 40859382›Full record

ArticleDiabetology & metabolic syndrome2025

The association of bone mineral density with cardiovascular disease and mortality among individuals with/without type 2 diabetes: a population-based retrospective cohort.

Ran Chen, Qingshan Guo, Chuanqing Bai, Jie Li, Yiyang Chen, Jiaxin Tan, Lianyang Zhang, Jun Fei, Siru Zhou

Erratum issuedAbstract read
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In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ran Chen *War Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China.
Qingshan Guo *War Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China.
Chuanqing Bai *Department of Rehabilitation Medicine, Daping Hospital, Army Medical University of PLA, Chongqing, 400042, P. R. China.
Jie LiBattalion 2021 of the Cadet Brigade, Third Military Medical University (Army Medical University), Chongqing, P. R. China.
Yiyang ChenBattalion 2022 of the Cadet Brigade, Third Military Medical University (Army Medical University), Chongqing, P. R. China.
Jiaxin TanWar Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China.
Lianyang ZhangWar Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China.
Jun FeiWar Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China. feijun@tmmu.edu.cn.
Siru ZhouWar Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China. zhousiru1025@163.com.

Funding

Central Government guided local Science and technology development project 2023ZYD0288Chongqing Acute and Critical Care Clinical Medical Research Center 3354181Chongqing Appropriate Technology Promotion Project 2018jstg019Chongqing Science and Technology Bureau and Health Commission joint major project of traditional Chinese medicine research 2023DBXM010Chongqing Technology innovation and application development Sichuan-Chongqing science and technology innovation cooperation plan project CSTB2024TIAD-CYKJCXX0036
6 · The paper itself

Abstract

objectivesWhile type 2 diabetes (T2D) disrupts bone metabolism, T2D individuals often exhibit normal or elevated bone mineral density (BMD), complicating the relationship between BMD and cardiovascular disease (CVD). This study aimed to clarify the associations of BMD with CVD and mortality (CVM) in individuals with/without T2D. STUDY

designa retrospective cohort study.

methodsT2D and non-type 2 diabetes (NT2D) individuals were selected from the National Health and Nutrition Examination Survey (2005-2018). They were classified into three groups based on femoral neck BMD: T1(< 0.8 g/cm²), T2(0.8-1 g/cm²), and T3(≥ 1 g/cm²). Weighted multivariate analysis examined the association between BMD and CVD/CVM, while restricted cubic spline assessed their nonlinearity between BMD and CVM.

resultsThe study comprised 10,586 participants (NT2D: 8,006; T2D: 2,580). During a median follow-up of 125 months, CVD accounted for 201 and 128 deaths in NT2D and T2D groups. After multivariate adjustment, lower BMD was associated with higher CVD risk in the both groups, while higher BMD exhibited lower risk. However, higher BMD in T2D group was linked to increased CVD risk in males[OR

conclusionsWhile low BMD serve as a risk factor for CVD and mortality in NT2D/T2D individuals, high BMD may be associated with elevated cardiovascular risk in T2D patients.

Indexed as

Bone mineral densityCardiovascular diseasesCardiovascular mortalityType 2 diabetes

Identifiers

PMID40859382
PMCPMC12382062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.