Evidence map›Paper›PMID 40859359›Full record

ArticleArthritis research & therapy2025

KLF11 alleviates rheumatoid arthritis by regulating M1 macrophage polarization via downregulation of YAP1 expression.

Xiaodan Liu, Fang Fang, Hongmei Duan, Chunling Wu, Haina Liu, Shuang Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Xiaodan LiuClinical Laboratory Department, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Fang FangDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, No.155, Nanjingbei Street, Heping District, Shenyang , Liaoning Province, 110001, China.
Hongmei DuanDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, No.155, Nanjingbei Street, Heping District, Shenyang , Liaoning Province, 110001, China.
Chunling WuDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, No.155, Nanjingbei Street, Heping District, Shenyang , Liaoning Province, 110001, China.
Haina LiuDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, No.155, Nanjingbei Street, Heping District, Shenyang , Liaoning Province, 110001, China.
Shuang DingDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, No.155, Nanjingbei Street, Heping District, Shenyang , Liaoning Province, 110001, China. fay_ds@163.com.

Funding

Scientific Research Project of the Educational Department of Liaoning Province LJKMZ20221198
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease, primarily impacting joints and bones. The Gene Expression Omnibus (GEO) datasets (GSE55235 and GSE10500) revealed that KLF11 expression was lower in the patients with RA, which was confirmed by the collected RA samples. However, KLF11's function and molecular mechanism in RA remain to be elucidated. In our study, we investigated this issue using in vivo and in vitro models. Our findings consistently demonstrated the downregulation of KLF11 in mice with collagen-induced arthritis (CIA). Overexpression of KLF11 reduced the arthritis severity and the extent of bone destruction in mice with CIA, whereas KLF11 knockdown exerted the opposite effect. Additionally, it was noted to inhibit M1 macrophage polarization and the ERK pathway both in vivo and in vitro. The JASPAR database indicated the potential for KLF11 to bind to the YAP1 promoter region. ChIP and dual-luciferase reporter assays confirmed the binding of KLF11 to the promoter of YAP1. Further experiments demonstrated that KLF11 negatively regulated YAP1 expression in THP-1 cells. YAP1 overexpression partially reversed the KLF11's inhibitory effect on the ERK signaling pathway and M1 macrophage polarization in vitro. KLF11 may be a promising therapeutic target for RA.

Indexed as

Adaptor Proteins, Signal TransducingArthritis, ExperimentalArthritis, RheumatoidMacrophagesTranscription FactorsAnimalsCell Cycle ProteinsDown-RegulationHumansMaleMiceMice, Inbred DBATHP-1 CellsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsTranscription FactorsYAP1 protein, humanYap1 protein, mouseYAP-Signaling ProteinsERK signaling pathwayKrüppel-like factor 11Macrophage polarizationRheumatoid arthritisYes-associated protein 1

Identifiers

PMID40859359
PMCPMC12379315

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.