ArticleLipids in health and disease2025
The relationship between the triglyceride to high-density lipoprotein cholesterol ratio and positive blood or pus cultures in patients with pyogenic liver abscess.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Case Report: Massive subcapsular hepatic hematoma after spontaneous rupture of pyogenic liver abscess in a healthy young woman.Frontiers in medicine · 2025Article
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7 authors.
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Abstract
BACKGROUND/
aimsHigh triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C), and an elevated TG/HDL-C ratio are linked to increased systemic inflammation and impaired immune function. However, the clinical significance of the TG/HDL-C ratio in pyogenic liver abscess (PLA) remains poorly defined.
methodsIn this multicenter, cross-sectional study of 2,201 cases of PLA, logistic regression, smoothed curve fitting, and comprehensive sensitivity analyses were employed to assess the relationship between the baseline TG/HDL-C ratio and positive blood or pus cultures. Subgroup analyses and interaction tests were performed to evaluate the robustness of the findings.
resultsLogistic regression showed that the TG/HDL-C ratio was positively associated with blood or pus culture positivity in PLA [odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02-1.06, P < 0.001. Smoothed curve fitting revealed a nonlinear dose-response relationship, with an inflection point at 9.2. Below this threshold, the TG/HDL-C ratio remained significantly associated with culture positivity (OR = 1.1, 95% CI: 1.1-1.2, P < 0.001). Sensitivity analyses and interaction tests confirmed these results.
conclusionsThe TG/HDL-C ratio demonstrates a nonlinear relationship with the risk of positive blood or pus cultures in patients with PLA, with a pivotal threshold value identified at 9.2. This readily obtainable ratio may help clinicians individualize management strategies and facilitate timely interventions for PLA patients in this at-risk group, leading to improved health outcomes for this vulnerable population.
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