ArticleBMC veterinary research2025
Isolation of porcine intestinal Lactobacillus salivarius and antimicrobial potential of its biosurfactant.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- In Vitro and In Vivo Evaluation ofMicroorganisms · 2026Article
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Authors and funding
9 authors.
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Abstract
backgroundLactobacillus salivarius (L. salivarius) is a probiotic widely colonized in the gastrointestinal tracts of humans and animals. Its biosurfactant (BS) exhibits antibacterial and antiviral activities, along with advantages such as biodegradability, non-toxicity, and stability. Porcine circovirus type 2 (PCV2) is a major pathogen in swine farms, causing immunosuppression or immune dysfunction. PCV2-positive herds exhibit elevated susceptibility, often accompanied by severe secondary bacterial infections. To explore novel antimicrobial biologics for enhancing swine immunity, this study isolated a biosurfactant-producing Lactobacillus strain from the intestines of PCV2-infected piglets using the calcium carbonate plate method, and analyzed the anti-microbial activity of the biosurfactant.
resultsA strain of biosurfactant-producing L. salivarius was successfully isolated from the ileum of PCV2-infected piglets. The extracted BS from the isolate demonstrated surface tension-reducing properties, forming spreading zones or dispersions on vegetable oil. The antimicrobial experiment showed that at the concentrations of 1.56 - 50 mg/mL, BS inhibited the growth of porcine E. coli and S. suis by 46.01% - 95.06% and 41.06% - 81.64%, respectively. Furthermore, BS of 6.25-12.5 mg/mL significantly inhibited PCV2 replication in PK-15 cells. These findings suggest that L. salivarius is a promising probiotic candidate for improving swine immune status and developing novel alternatives to conventional antimicrobial agents.
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