Evidence map›Paper›PMID 40859215›Full record

ArticleBMC oral health2025

Laboratory performance of novel injectable keratin nanoparticle from poultry feathers loaded-alginate composite hydrogel as a pulpotomy filling biomaterial for dentin regeneration.

Marwa S Naga, Hala M Helal, Elbadawy A Kamoun, Maha Abdel Moaty, Samia S Abdel Rehim Omar, Ahmed Z Ghareeb, Esmail M El-Fakharany, Mona Mohy El Din

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marwa S NagaDental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Hala M HelalIndustrial Pharmacy Dep, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Elbadawy A KamounDepartment of Chemistry, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia. ekamoun@kfu.edu.sa.
Maha Abdel MoatyDental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Samia S Abdel Rehim OmarOral Biology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Ahmed Z GhareebCentre of Excellence for Drug Preclinical Studies (CE-DPS), Pharmaceutical and Fermentation Industry Development Centre, City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab City, Alexandria, 21934, Egypt.
Esmail M El-FakharanyProtein Research Department, Genetic Engineering and Biotechnology Research Institute GEBRI, City for Scientific Research and Technology Applications, New Borg Al-Arab City, Alexandria, 21934, Egypt.
Mona Mohy El DinDental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. mona.mohy@alexu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious medicaments have been utilized as an aid for wound healing following vital pulp treatment. Many of them are synthetic in origin and have disadvantages as limited amount of cytotoxicity and great expense. Hence, to tackle these drawbacks, naturally derived blended scaffolds have been employed in renovative dental field. Current research attempts to synthesize and characterize physicochemical performance of the newly injectable alginate hydrogel loaded with chicken feather regenerated keratin nanoparticles (nKer NPs) in different percentages as a new pulpotomy agent.

methodsAlginate hydrogels were developed by dissipating alginate powder in alcohol distilled water including nKer NPs at 0.5, 1.0 and 1.5 wt%. The obtained mix was agitated and sustained at nighttime in water-bath at 50

resultsAlginate/nKer NPs (1.0 wt%) loaded group (IIb) exhibited wide (243 μm), open pores with adequate interconnectivity. Thermal stability (T

conclusionThe favorable experimental behavior of the injectable alginate/nKer NPs (1.0 wt%) hydrogel advocated it as encouraging applicant for pulpotomy promoting the regeneration of dentin in clinical implementations.

Indexed as

AlginatesBiocompatible MaterialsDentinFeathersHydrogelsKeratinsNanoparticlesAnimalsCell SurvivalChickensDental PulpHumansMaterials TestingMicroscopy, Electron, ScanningRegenerationSpectroscopy, Fourier Transform InfraredAlginatesBiocompatible MaterialsHydrogelsKeratinsChicken feathersDentin regenerationKeratin nanoparticlesPoultry wastesRegenerative pulpotomy

Identifiers

PMID40859215
PMCPMC12379472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.