ArticleBMC oral health2025
The potential association between oral lichen planus and vaccination against hepatitis B. A real-world study analyzing data from approximately 200,000 patients.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
backgroundOral lichen planus (OLP) and oral lichenoid lesions (OLL) are immune-mediated conditions that may occur in response to medications or vaccines. Although hepatitis B vaccination is widely considered safe, isolated case reports have suggested a possible link to OLP/OLL. However, large-scale epidemiologic data are lacking.
methodsA matched-cohort study was conducted using real-world data from the TriNetX database. The initial dataset included 112,444 patients who received hepatitis B vaccination and 7,002,541 unvaccinated individuals. After one-to-one propensity score matching, each cohort comprised 112,444 subjects. The primary outcome was the onset of OLP/OLL within 30 days post-index, identified via ICD-10 codes and confirmed histologically.
resultsOLP/OLL occurred in 423 vaccinated patients (0.736%) and in 316 unvaccinated individuals (0.281%), with a significant group difference (p < 0.001, Log-Rank test). The risk ratio was 1.400 (95% CI: 1.210-1.619), and the odds ratio was 1.401 (95% CI: 1.211-1.622).
conclusionThis study demonstrates a statistically significant but modestly increased risk of OLP/OLL following hepatitis B vaccination. Given the small effect size and observational design, the findings should be interpreted as hypothesis-generating. Further prospective studies are warranted.
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