Evidence map›Paper›PMID 40859085›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Ultrasound Contrast Agents in Mice: Bridging the Gap from Preclinical Research to Clinical Translation.

Dieter Fuchs, Philippe Trochet, Peter Kesa, Caroline E O'Riordan

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dieter FuchsFujifilm VisualSonics BV, Amsterdam, The Netherlands. dieter.fuchs@fujifilm.com.
Philippe TrochetFujifilm VisualSonics BV, Amsterdam, The Netherlands.
Peter KesaFujifilm VisualSonics BV, Amsterdam, The Netherlands.
Caroline E O'RiordanFujifilm VisualSonics BV, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast-enhanced ultrasound (CEUS) is a powerful imaging modality, increasingly utilized in preclinical research, particularly in murine models. While CEUS offers numerous advantages such as real-time imaging, noninvasiveness, and lack of ionizing radiation, the lack of standardized protocols tailored specifically to the mouse presents a challenge. This work offers a dedicated protocol for CEUS in mice to enhance the reproducibility, reliability, and translatability of preclinical findings.This dedicated protocol addresses the entire CEUS workflow, from contrast agent preparation to animal handling, contrast agent administration, and CEUS imaging parameters.With the proposed standardized workflow establishing guidelines and best practices, researchers can leverage CEUS more effectively, thereby accelerating translatability and the development of innovative approaches to disease characterization, treatment, and management.

Indexed as

Contrast MediaTranslational Research, BiomedicalAnimalsDisease Models, AnimalMiceReproducibility of ResultsUltrasonographyWorkflowContrast MediaCEUSContrast agentMousePerfusionProtocolUltrasound

Identifiers

PMID40859085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.