Evidence map›Paper›PMID 40859064›Full record

ArticleEuropean journal of pediatrics2025

Serum ferritin in children with juvenile idiopathic arthritis: a promising subtype-specific marker of disease activity.

Maria Francesca Gicchino, Maria Grazia Fusco, Marica Esposito, Alessia Amodio, Emanuele Miraglia Del Giudice, Alma Nunzia Olivieri, Anna Di Sessa

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Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Maria Francesca GicchinoDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Maria Grazia FuscoDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marica EspositoDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alessia AmodioDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Emanuele Miraglia Del GiudiceDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alma Nunzia OlivieriDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Anna Di SessaDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. anna.disessa@unicampania.it.ORCID http://orcid.org/0000-0002-5877-3757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While serum ferritin has been established as a marker of disease activity in adults with rheumatoid arthritis, evidence on its role in children with Juvenile Idiopathic Arthritis (JIA) remains limited-particularly among non-systemic subtypes. We aimed to investigate the potential usefulness of serum ferritin levels as a marker of disease activity across the full spectrum of JIA subtypes in children. We retrospectively evaluated 139 children with JIA classified according to the International League of Association for Rheumatology (ILAR) criteria attending our Rheumatology Clinic. A comprehensive assessment was performed. Patients were classified by ILAR subtypes, and disease activity was assessed using JADAS-10 with standard cut-offs. Increased serum ferritin levels were observed in Still's disease (sJIA) and rheumatoid factor (RF)-positive polyarthritis patients compared to other subtypes (p < 0.0001). The highest serum ferritin levels were demonstrated in sJIA and RF-positive polyarthritis patients with high disease activity (p = 0.003). A positive correlation was found between serum ferritin and JADAS-10 score in the study population (r

conclusionIncreased baseline serum ferritin levels were found in children with sJIA and RF-positive polyarthritis exhibiting high disease activity, compared to those with other JIA subtypes. These preliminary findings suggest serum ferritin may as a valuable marker of disease activity across JIA subtypes in pediatric clinical practice. Further prospective studies are warranted to confirm its usefulness in monitoring disease course and treatment response. WHAT IS KNOWN: • Serum ferritin has been recognized as a marker of disease activity in adult patients with RA. • Evidence on the role of ferritin as disease activity marker in children with JIA remains limited, particularly for non-systemic forms. • Limited data exist on TPHA prevalence. WHAT IS NEW: • Serum ferritin levels are associated with high disease activity in children with sJIA and RF positive polyarthritis. • Serum ferritin may serve as a useful marker of disease activity across JIA subtypes, particularly in sJIA and RF-positive polyarthritis, potentially improving the challenging management of these high-risk patients.

Indexed as

Arthritis, JuvenileFerritinsAdolescentBiomarkersChildChild, PreschoolFemaleHumansMaleRetrospective StudiesSeverity of Illness IndexBiomarkersFerritinsChildrenDisease activityFerritinJuvenile idiopathic arthritisMarkerSubtypes

Identifiers

PMID40859064

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