SynthesisArchives of gynecology and obstetrics2025
Chemotherapy in elderly patients with early breast cancer: a systematic review.
Synthesis in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Real-world insights into bone marrow carcinomatosis in metastatic breast cancer: a retrospective analysis from two large university breast cancer centers.Journal of cancer research and clinical oncology · 2026Article
- Age-dependent differences in survival of patients with early breast cancer: analysis of SUCCESS A, B, C trials.Archives of gynecology and obstetrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast cancer is the most common cancer affecting elderly patients. However, they may not receive optimal oncological care. Reasons might be comorbidities, limited compliance with clinical guidelines, and insufficient evidence for guideline recommendations. In the present review, the evidence for the clinical benefit of chemotherapy (CHT) in the population of elderly women with breast cancer was examined.
methodsA systematic review of relevant literature in English identifying studies published from January 2000 to April 2023 was conducted. The analysis included studies on the application of CHT, effects on survival, and toxicities. We searched PubMed databases for relevant publications. In total, 24 studies were included in the present review.
resultsThe benefit of CHT in elderly patients was inconsistent. Results of this review indicate evidence for the benefit of CHT in healthy elderly patients with high-risk breast cancer (BC) and specific subtypes such as triple-negative or HER2-positive BC. Data from studies on pathological complete response rates (pCR) or surgical downstaging rates after neoadjuvant chemotherapy (NACT) in different age groups are controversial.
conclusionResults from studies on the effects of CHT in elderly patients are insufficient to draw differentiated conclusions due to heterogeneity of the definition for "elderly" patients, the application of different drugs and dosages. Patients with high-risk BC may benefit from CHT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.