ArticleThe EMBO journal2025
Donor transcription suppresses D-loops in cis and promotes genome stability.
Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- R-loops and D-loops: a delicate balance in genomic stability and instability.Cell communication and signaling : CCS · 2026Review
- Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae.The EMBO journal · 2026Article
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2 authors.
Funding
Abstract
DNA is a substrate for competing protein-mediated activities. Whether and how transcription and the synaptic steps of recombination collide or are coordinated has not been investigated. Here, using a controlled break induction system and physical detection of D-loop DNA joint molecules in S. cerevisiae, we show that donor transcription by RNA polymerase II strongly and acutely suppresses D-loops in cis. The extent of this suppression depends on the orientation of transcription, suggesting the preferential usage of one end for the repair of DNA break in transcribed regions. Transcription-mediated D-loop suppression does not rely on endogenous transcription factors, the RNA product, or RNA:DNA hybrids. It is independent of, and can be more potent than the conserved trans D-loop-disruption factors Sgs1-Top3-Rmi1
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