ArticleLasers in medical science2025
5-ALA mediated PDT induces pyroptosis in colorectal cancer cells by targeting the caspase-1/GSDMD pathway.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Pyroptosis as a double-edged sword in colorectal cancer: Molecular mechanisms and therapeutic opportunities.Apoptosis : an international journal on programmed cell death · 2026Review
- 5-Aminolevulinic Acid-Mediated Photodynamic Therapy Induces Ferroptosis in Oral Leukoplakia and Oral Squamous Cell Carcinoma.Antioxidants (Basel, Switzerland) · 2026Article
- Autophagy regulation of pyroptosis and ferroptosis: a new strategy for colorectal cancer treatment.Apoptosis : an international journal on programmed cell death · 2026Review
- Photodynamic therapy: a promising alternative for high-grade squamous intraepithelial lesion treatment.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Photodynamic therapy (PDT) is a minimally invasive treatment modality based on photochemical reactions that damage specific tumour tissues. Pyroptosis is a type of programmed death that relies on the activation of cysteine-containing aspartate proteolytic enzymes (caspases) and cleavage of the gasdermin protein family members. However, the mechanism of 5-aminolevulinic acid (5-ALA)-mediated PDT-induced pyroptosis in colorectal cancer is not well understood. Here, we found that 5-ALA-mediated PDT can induce pyroptosis in colorectal cancer cells, characterized by the appearance of pyroptotic bubbles and the detection of the release of cellular contents and inflammatory factors. Mechanistically, PDT activates caspase-1 and cleaves gasdermin D (GSDMD), and the release of N-GSDMD triggers pyroptosis in colorectal cancer cells. In addition, inhibition of this pathway in vivo can attenuate the therapeutic effect of PDT. In summary, we investigated the role of GSDMD in PDT-mediated pyroptosis in CRC cells, and the results showed that 5-ALA-mediated PDT induces pyroptosis in colorectal cancer cells by targeting the caspase-1/GSDMD pathway. This study may provide a reference for the clinical application of PDT in CRC treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.