Evidence map›Paper›PMID 40858937›Full record

ArticleNature chemical biology2026

Oncometabolite 5-IP

Hongyun Zhang, Bobo Zhang, Yuebo Zhao, Yang Su, Yifan Peng, Xiaoli Yang, Hongming Zhao, Hongyu Liu, Jie Feng, Hongjing Pei and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Design principles imprinted by evolution.Nature chemical biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hongyun Zhang *School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Bobo Zhang *School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yuebo Zhao *School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yang Su *School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yifan PengKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing, China.
Xiaoli YangSchool of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Hongming ZhaoDepartment of Biology, Institute of Plant and Food Science, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Hongyu LiuNational Institute of Biological Sciences, Beijing, China.
Jie FengNational Institute of Biological Sciences, Beijing, China.
Hongjing PeiKey University Laboratory of Metabolism and Health of Guangdong, Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Wenyong ZhangKey University Laboratory of Metabolism and Health of Guangdong, Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Niu HuangNational Institute of Biological Sciences, Beijing, China.ORCID 0000-0002-6912-033X
Kai JiangDepartment of Biology, Institute of Plant and Food Science, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0001-9901-5293
Masatoshi ItoDepartment of Neurology, Tokai University School of Medicine, Isehara, Japan.
Guizhen LiuInstitute of Organic Chemistry, CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
Nicolas JorkInstitute of Organic Chemistry, CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3717-443X
Karen E AndersonBabraham Institute, Cambridge, UK.ORCID 0000-0002-7394-6660
Li ZhaoDepartment of Thyroid and Neck Oncology, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Eiichiro NagataDepartment of Neurology, Tokai University School of Medicine, Isehara, Japan.
Henning J JessenInstitute of Organic Chemistry, CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-1025-9484
Philip T HawkinsBabraham Institute, Cambridge, UK.
Changzheng DuCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Feng RaoSchool of Life Sciences, Southern University of Science and Technology, Shenzhen, China. raof@sustech.edu.cn.ORCID 0000-0002-6038-6406

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) CIBSS, EXC-2189, Project ID 390939984National Natural Science Foundation of China (National Science Foundation of China) 32122026National Natural Science Foundation of China (National Science Foundation of China) 32170590
6 · The paper itself

Abstract

E-cadherin downregulation is an epithelial-mesenchymal transition hallmark canonically attributed to transcriptional repression. Here we delineate a metabolite-driven endocytic route of E-cadherin downregulation in inflammation-associated colorectal cancer (CRC). Specifically, IP

Indexed as

CadherinsColorectal NeoplasmsEndocytosisInositol PhosphatesPhosphoric Monoester HydrolasesAnimalsbeta CateninColitisDextran SulfateHumansMiceMice, Inbred C57BLPhosphotransferases (Alcohol Group Acceptor)beta CateninCadherinsDextran SulfateInositol PhosphatesPhosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.