ArticlePediatric research2026
Long-term impact of necrotizing enterocolitis on somatosensory function in preterm born children.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- AI-2 combined with Lactobacillus rhamnosus GG remodels gut microbiota structure to alleviate intestinal oxidative stress injury in a mouse necrotizing enterocolitis model.Journal of translational medicine · 2026Article
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8 authors.
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Abstract
backgroundNecrotizing enterocolitis (NEC) is a painful intestinal disease in preterm infants that causes severe prolonged pain requiring high amounts of analgesics. In a critical stage of neurodevelopment, pain and analgesics potentially impact sensory development. This study compared somatosensory function and sensory processing in preterm-born children with and without a history of NEC, as well as key self-/parent-reported outcomes.
methodsIn this cross-sectional cohort study, preterm-born children (6-15 years old) with NEC were matched with controls. Each child underwent quantitative sensory testing in a mobile research lab at home. Parents completed questionnaires on their child's sensory processing, behavior, executive function, chronic pain, and (health-related) quality of life.
resultsSixty-six children (22 NEC, 44 control) participated. Children with a history of NEC exhibited lower cold pain thresholds (β = -11 °C, 95% CI [-21;-1.0], p = 0.03) compared to those without NEC. Moreover, they exhibited poorer executive function, though no longer significant after correcting for confounders. No significant differences were found in sensory processing, behavioral problems, chronic pain, and (health-related) quality of life.
conclusionChildren with a history of NEC are less sensitive to cold pain, but have otherwise similar somatosensory function and sensory processing to other preterm-born children. Most self- and parent-reported outcomes are comparable to those of other preterm-born children without NEC. IMPACT: Necrotizing enterocolitis in preterm infants lastingly alters their (cold) pain sensitivity. Most self- and parent-reported outcomes of children with a history of NEC are similar to those of other preterm-born children. Sensory processing and behavioral problems are common among both preterm-born children with and without NEC history. Our results warrant the search for protective strategies during NICU admission and thorough follow-up after NICU discharge.
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