Evidence map›Paper›PMID 40858875›Full record

SynthesisNeurosurgical review2025

Outcomes following traumatic brain injury in patients with Pre-Injury antiplatelets versus anticoagulants: A systematic review and Meta-Analysis.

Stavros Matsoukas, Sean Inzerillo, Arianne Boylan, Patrick C Reid, Konstantinos Margetis, Divaldo Camara

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stavros MatsoukasDepartment of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY, 10029, USA. stavrosmatsoukas@hotmail.com.ORCID http://orcid.org/0000-0001-5902-0637
Sean InzerilloSchool of Medicine, State University of New York Downstate Health Sciences University, New York, USA.
Arianne BoylanDepartment of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY, 10029, USA.
Patrick C ReidDepartment of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY, 10029, USA.
Konstantinos MargetisDepartment of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-3715-8093
Divaldo CamaraDepartment of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY, 10029, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Management of traumatic brain injury (TBI) patients on pre-TBI antithrombotic medications poses a clinical challenge in everyday practice. However, the safety profiles of antiplatelets (APs) have not been systematically studied and compared to anticoagulants (ACs) in this patient population. In this PRISMA-compliant systematic review the EMBASE and MEDLINE databases were systematically queried to identify comparative studies in patients with TBI and pre-injury AP and AC medications. Meta-analysis with random effect models were conducted for all outcomes. Forest plots were utilized to visually represent each study's effect and pooled estimates. Intracranial hemorrhage rates were statistically significantly higher for patients on single AP vs. AC (AP 19.7%; AC 9.3%; OR 1.35; CI 1.02-1.78; I

Indexed as

AnticoagulantsBrain Injuries, TraumaticPlatelet Aggregation InhibitorsHumansIntracranial HemorrhagesTreatment OutcomeAnticoagulantsPlatelet Aggregation Inhibitors

Identifiers

PMID40858875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.