Evidence map›Paper›PMID 40858865›Full record

ReviewAntonie van Leeuwenhoek2025

Dengue virus: structure, genome, evolution and challenges to control and prevent transmission.

Khalida Umar, Tanisha Sutradhar, P Prakash, M Bavanilatha, A U Hemamalani, R Subha Prakashini, T Thangam, Krupakar Parthasarathy

Abstract readReview
PubMed Publisher
In one paragraph

Review in Antonie van Leeuwenhoek, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khalida Umar *Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India.
Tanisha Sutradhar *Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India.
P PrakashDepartment of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India.
M BavanilathaDepartment of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India.
A U HemamalaniCentre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, India.
R Subha PrakashiniCentre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, India.
T ThangamCentre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, India.
Krupakar ParthasarathyCentre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, India. pkrupakar.cddd@sathyabama.ac.in.ORCID http://orcid.org/0000-0003-1846-800X

Funding

Indian Council of Medical Research No. 6/9-7 (328)/2023/ECD-II, VIR/COVID-19/33/2021/ECD-I).
6 · The paper itself

Abstract

Dengue virus (DENV) is a major global health threat, primarily transmitted by Aedes mosquitoes. It manifests in mild to severe forms, including dengue hemorrhagic fever and dengue shock syndrome, causing significant morbidity and mortality. With four serotypes (DENV-1 to DENV-4), the virus exhibits rapid genetic evolution, complicating vaccine development and disease control. This review explores the structural and genomic characteristics of DENV, emphasizing its evolutionary pressures, immune evasion mechanisms, and emerging strains. The virus's adaptation to environmental and host factors has led to increased outbreaks, notably in tropical regions. Global warming and urbanization have exacerbated the spread, challenging current vector control strategies. Laboratory diagnosis remains complex, relying on molecular and serological techniques with varying sensitivity. The lack of effective antiviral drugs and universally protective vaccines highlights critical gaps in disease management. Ongoing genomic surveillance and integrated control strategies are crucial for mitigating the impact of new DENV variants. This review highlights the importance of investigating the effect of emerging dengue strains on society, as well as how environmental factors exacerbate their severity.

Indexed as

DengueDengue VirusEvolution, MolecularGenome, ViralAedesAnimalsHumansImmunity, InnateMosquito VectorsAedes aegyptiAedes albopictusDengue virus (DENV)Flavivirus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.