Evidence map›Paper›PMID 40858863›Full record

ArticleSports medicine (Auckland, N.Z.)2026

Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.

John J Leddy, Mohammad N Haider, Haley M Chizuk, Muhammad S Z Nazir, Phillip Worts, Barry S Willer, Blair D Johnson

Abstract read
In one paragraph

Article in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John J LeddyUBMD Orthopaedics and Sports Medicine, SUNY Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.ORCID 0000-0002-0370-1289
Mohammad N HaiderUBMD Orthopaedics and Sports Medicine, SUNY Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA. haider@buffalo.edu.ORCID 0000-0001-7190-0004
Haley M ChizukUBMD Orthopaedics and Sports Medicine, SUNY Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.ORCID 0000-0003-2113-0536
Muhammad S Z NazirUBMD Orthopaedics and Sports Medicine, SUNY Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.ORCID 0000-0001-9565-0900
Phillip WortsTallahassee Orthopedic Clinic, Tallahassee, FL, USA.ORCID 0000-0002-5571-5404
Barry S WillerDepartment of Psychiatry, SUNY Buffalo Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-9586-8448
Blair D JohnsonDepartment of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-1731-4415

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
NCATS NIH HHS UL1TR001412NINDS NIH HHS 1R01NS094444
6 · The paper itself

Abstract

backgroundSymptom-limited exercise intolerance is a physiological sign of sport-related concussion. Possible etiologies include rest-induced aerobic deconditioning and/or impaired cardiopulmonary function.

objectiveThis study examined cardiovascular and respiratory function at rest and during progressive cycle ergometer exercise in adolescents within 10 days of sport-related concussion compared with non-concussed athletes.

methodsConcussed participants (n = 26, 15.4 ± 1.1 years, 54% male, 7.3 ± 1.8 days from injury) and control participants (n = 24, 15.8 ± 1.6 years, 58% male) performed the Buffalo Concussion Bike Test. Blood pressure, heart rate, stroke volume, cardiac output, respiratory rate, minute ventilation, oxygen consumption, and end-tidal CO

resultsConcussed participants exercised for 16.24 ± 5.6 min, experienced a greater than 2-point (on a 0-10 scale) exacerbation of their concussion symptoms at their final minute, and reported higher perceived exertion throughout exercise versus controls. Controls exercised for 25.08 ± 7.0 min up to voluntary exhaustion without reporting any concussion-like symptoms. Concussed participants' cardiovascular and respiratory parameters did not differ at rest versus controls, but concussed participants had higher minute ventilation and their blood pressure plateaued at lower values during the first 10 min of exercise.

conclusionsNo evidence of aerobic deconditioning was found within 10 days of injury. Our study found attenuated cardiopulmonary responses to progressive aerobic exercise, which may be a cause for exercise intolerance in concussed adolescent athletes. Additional research is warranted to determine if this may be related to altered autonomic nervous system regulation.

Indexed as

Athletic InjuriesBrain ConcussionExerciseAdolescentBlood PressureCardiac OutputCase-Control StudiesExercise TestExercise ToleranceFemaleHeart RateHumansMaleOxygen ConsumptionRespiratory RateStroke Volume

Identifiers

PMID40858863
PMCPMC12913255

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.