Evidence map›Paper›PMID 40858767›Full record

ArticleScientific reports2025

Human chorion and placental mesenchymal stem cells conditioned media suppress cell migration and invasion by inhibiting the PI3K/AKT pathway in cholangiocarcinoma.

Tanachapa Jantalika, Sirikul Manochantr, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Somchai Pinlaor, Weerachai Saijuntha, Luminita Paraoan, Chairat Tantrawatpan

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Tanachapa JantalikaDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Sirikul ManochantrDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Pakpoom KheolamaiDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Duangrat TantikanlayapornDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Somchai PinlaorDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Weerachai SaijunthaFaculty of Medicine, Mahasarakham University, Maha Sarakham, 44000, Thailand.
Luminita ParaoanDepartment of Life Sciences, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M1 5GD, UK. L.Paraoan@mmu.ac.uk.
Chairat TantrawatpanDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand. tchairat@tu.ac.th.

Funding

Thailand Science Research and Innovation (TSRI) Fundamental Fund, fiscal year 2024 TUFF 55/2567
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is an aggressive bile duct malignancy with poor survival rates due to late detection, rapid metastasis, and treatment resistance. Therefore, new therapeutic strategies are needed to improve treatment outcomes. Previous studies have reported that mesenchymal stem cells (MSCs) secrete several soluble factors that modulate intracellular signaling pathways that are critical for the regulation of cancer cell function. The present study aimed to investigate the effects and molecular mechanisms of conditioned media from chorion-derived human MSCs (CH-CM) and placenta-derived human MSCs (PL-CM) on the migration and invasion of human CCA cells. We found that both CH-CM and PL-CM suppress cell migration and invasion in three CCA cell lines (KKU100, KKU213A and KKU213B) by increasing E-cadherin expression and decreasing the expression of several factors involved in the epithelial-mesenchymal transition process, including ZEB1, ZEB2, N-cadherin, vimentin, and MMP-2. The effects of CH-CM and PL-CM were mediated, at least in part, through the suppression of the PI3K/AKT signaling pathway in CCA cells. Our findings suggest that soluble factors derived from CH-MSCs and PL-MSCs could be used in combination with other conventional treatments to diminish the invasiveness of CCA cells, thus improving the therapeutic outcome and increasing survival in CCA patients.

Indexed as

Bile Duct NeoplasmsCell MovementCholangiocarcinomaChorionMesenchymal Stem CellsPhosphatidylinositol 3-KinasesPlacentaProto-Oncogene Proteins c-aktSignal TransductionCell Line, TumorCulture Media, ConditionedEpithelial-Mesenchymal TransitionFemaleHumansNeoplasm InvasivenessPregnancyCulture Media, ConditionedPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBile duct cancerInvasionMesenchymal stem cellsMigrationPI3K/AKT pathway

Identifiers

PMID40858767
PMCPMC12381114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.