ReviewEuropean journal of pediatrics2025
Hearing loss: a global view for gene therapy approaches and challenges.
Review in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Gut-Ear Axis: From Dysbiosis to Auditory and Vestibular Disorders.International journal of molecular sciences · 2026Review
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing loss (HL) is a global issue that affects the quality of life. The incidence of the prelingual form reaches 1: 500 live births, where inherited HL represents the most frequent form. The early diagnosis and intervention to restore hearing might help in reaching near-normal speech milestones in congenital HL cases. Current treatment includes using a hearing aid and cochlear implantation (CI). In spite of the improvement detected on using these treatments, hearing is never back to normal. Gene therapy is the most recent approach studied in an attempt to reach a radical cure for this health problem. The tremendous genetic heterogeneity beyond different types of HL renders gene therapy a challenging yet promising treatment approach. This review encompasses all aspects of this approach including the various strategies (gene-dependent and gene-independent approaches), vehicles used for delivery, routes of administration, drawbacks, and the challenges that remain to be addressed.
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Registered trials
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