Evidence map›Paper›PMID 40858650›Full record

ArticleScientific reports2025

Optimized deep learning for brain tumor detection: a hybrid approach with attention mechanisms and clinical explainability.

Aditya Jayesh Aiya, Nishant Wani, Mayur Ramani, Anuj Kumar, Sangeeta Pant, Ketan Kotecha, Ambarish Kulkarni

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Aditya Jayesh AiyaSchool of Computer Science Engineering and Applications, D Y Patil International University (DYPIU), Akrudi, Pune, 411044, Maharashtra, India.
Nishant WaniSchool of Computer Science Engineering and Applications, D Y Patil International University (DYPIU), Akrudi, Pune, 411044, Maharashtra, India.
Mayur RamaniSchool of Computer Science Engineering and Applications, D Y Patil International University (DYPIU), Akrudi, Pune, 411044, Maharashtra, India.
Anuj KumarSchool of Computer Science Engineering and Applications, D Y Patil International University (DYPIU), Akrudi, Pune, 411044, Maharashtra, India. anuj.kumar@dypiu.ac.in.
Sangeeta PantDepartment of Applied Sciences, Symbiosis Institute of Technology, Symbiosis International (Deemed University), Lavale, Pune, 412115, Maharashtra, India. pant.sangeet@gmail.com.
Ketan KotechaSymbiosis Centre for Applied AI, Symbiosis Institute of Technology, Symbiosis International (Deemed University), Lavale, Pune, 412115, Maharashtra, India.
Ambarish KulkarniSchool of Engineering, Swinburne University of Technology, Hawthorn, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain tumor classification (BTC) from Magnetic Resonance Imaging (MRI) is a critical diagnosis task, which is highly important for treatment planning. In this study, we propose a hybrid deep learning (DL) model that integrates VGG16, an attention mechanism, and optimized hyperparameters to classify brain tumors into different categories as glioma, meningioma, pituitary tumor, and no tumor. The approach leverages state-of-the-art preprocessing techniques, transfer learning, and Gradient-weighted Class Activation Mapping (Grad-CAM) visualization on a dataset of 7023 MRI images to enhance both performance and interpretability. The proposed model achieves 99% test accuracy and impressive precision and recall figures and outperforms traditional approaches like Support Vector Machines (SVM) with Histogram of Oriented Gradients (HOG), Local Binary Pattern (LBP) and Principal Component Analysis (PCA) by a significant margin. Moreover, the model eliminates the need for manual labelling—a common challenge in this domain—by employing end-to-end learning, which allows the proposed model to derive meaningful features hence reducing human input. The integration of attention mechanisms further promote feature selection, in turn improving classification accuracy, while Grad-CAM visualizations show which regions of the image had the greatest impact on classification decisions, leading to increased transparency in clinical settings. Overall, the synergy of superior prediction, automatic feature extraction, and improved predictability confirms the model as an important application to neural networks approaches for brain tumor classification with valuable potential for enhancing medical imaging (MI) and clinical decision-making.

Indexed as

Brain NeoplasmsDeep LearningImage Interpretation, Computer-AssistedMagnetic Resonance ImagingClassification AlgorithmsConvolutional Neural NetworksGliomaHumansImage Processing, Computer-AssistedMeningiomaPituitary NeoplasmsSupport Vector MachineTransfer Machine LearningAttention mechanismBrain tumor classificationDeep learningGrad-CAM visualizationMagnetic resonance imagingVGG16

Identifiers

PMID40858650
PMCPMC12381073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.