ArticleNature communications2025
Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the mouse frontal cortex.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Microglia extract neuronal proteolytic organelles via skoupocytosis.bioRxiv : the preprint server for biology · 2026Article
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- Multi-Omics Reveals Dysregulated Neurotransmitter Systems in Aging and CNS Disorders.Aging cell · 2026Article
- Discovery of Abundant Nano-scale Lymphatic-like Vessels in Brains.bioRxiv : the preprint server for biology · 2026Article
- Glial-Dopamine crosstalk: Astrocytic and microglial gatekeepers of neuroinflammation, plasticity, and motivation.AIMS neuroscience · 2026Review
- The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex.Brain, behavior, and immunity · 2025Article
- Potential roles for microglia in drug addiction: Adolescent neurodevelopment and beyond.Journal of neuroimmunology · 2025Review
- Molecular heterogeneity and development of the ventral tegmental area.Current opinion in behavioral sciences · 2025Article
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Abstract
Adolescence is a sensitive period for frontal cortical development and cognitive maturation, marked by heightened structural plasticity in the dopaminergic (DA) mesofrontal circuit. However, the cellular and molecular mechanisms underlying this plasticity remain unclear. Here, we show that microglia, the brain's innate immune cells, are highly responsive to mesofrontal DA signaling during adolescence. Longitudinal in vivo two-photon imaging in mice reveals that frontal cortical microglia increase their surveillance of the parenchyma and DA axonal boutons following rewarding experiences or optogenetic stimulation of DA axons. Microglial contacts with DA axons consistently precede bouton formation, and microglia-bouton interactions are regulated by D1- and D2-type DA receptors in adolescence and adulthood. Furthermore, microglial purinergic receptor P2RY12 signaling is necessary for enhanced microglial surveillance and DA bouton formation during adolescence. These results uncover bidirectional interactions between DA signaling and microglial surveillance that drive adolescent frontal plasticity and identify potential targets for restoring plasticity in adulthood.
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