ArticleRenal failure2025
Jiawei fangji huangqi decoction inhibits renal fibrosis and inflammation in UUO-induced fibrotic kidneys.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Renal fibrosis represents a common pathological pathway in various chronic kidney diseases (CKD). Jiawei Fangji Huangqi decoction (JFH) is a traditional Chinese herbal formula and has been clinically prescribed in China. The aim of this study was to determine the role of JFH in renal fibrosis using a unilateral ureteral obstruction (UUO) mouse model and explore its underlying mechanisms. In UUO mice, JFH was found to inhibit the accumulation of extracellular matrix (ECM) proteins, as demonstrated by Masson staining, and reduce the expression of fibrotic markers and TGF-β1 in obstructed kidneys, as confirmed by Western blotting analysis. JFH was closely correlated with the amelioration of epithelial-mesenchymal transition (EMT) as shown by Western blotting analysis. Mechanistic investigations
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