ArticleTranslational psychiatry2025
Limbic gray matter increases in response to cognitive-behavioral therapy in major depressive disorder.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder.JAMA network open · 2026Article
- Antidepressant use and dementia, cognitive measures, and neuroimaging outcomes: A population-based cohort study.Psychological medicine · 2026Article
- Changes in kynurenine pathway metabolites and brain structure in response to behavioral activation therapy.Brain, behavior, and immunity · 2026Article
- MRI-derived estimation of biological aging in patients with affective disorders in a 9-year follow-up - a prospective marker of future recurrence.Molecular psychiatry · 2026Article
- Vicious cycle: the bidirectional relationship and pathophysiological mechanisms of tinnitus and sleep disturbance.Frontiers in neurology · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Major depressive disorder (MDD) is related to volumetric decreases in (cortico-)limbic brain regions. In contrast to pharmacological and electroconvulsive therapy, little is known about the brain structural effects of psychotherapy and potential links to symptom improvements. In a naturalistic longitudinal study using structural magnetic resonance tomography, gray matter volume (GMV) and clinical measures were assessed in 30 outpatients with MDD before and after 20 cognitive-behavioral therapy (CBT) sessions. Data from 30 healthy controls was acquired. Region-of-interest analyses revealed significant GMV increases within patients for the right anterior hippocampus and the bilateral amygdala, resulting in a significant group-by-time interaction for the left amygdala (p ≤ 0.022). Simultaneously, analyses revealed volumetric decreases in the right posterior hippocampus (p = 0.016). While there were no associations with overall symptom improvement, right amygdala volume increases were slightly associated with improvements in identifying feelings (r
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