Evidence map›Paper›PMID 40858335›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Risks of prematurity and low birth weight associated with trimester-specific prenatal benzodiazepine exposure.

Vincent Chin-Hung Chen, Yi-Lung Chen, Kai-Liang Kao, Yi-Chen Lee, Mong-Liang Lu, Shu-I Wu, Robert Stewart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vincent Chin-Hung Chen *From the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).
Yi-Lung Chen *From the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).
Kai-Liang KaoFrom the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).
Yi-Chen LeeFrom the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).
Mong-Liang LuFrom the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).
Shu-I WuFrom the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart) t140@mmc.edu.tw.
Robert StewartFrom the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntrauterine exposure of the developing fetus or neonate to bendodiazepine may lead to fetal abnormalities or adverse reactions. We sought to investigate whether benzodiazepine use before or during different trimesters of pregnancy had different associations with incident preterm births (PTB) or small for gestational age (SGA) infants.

methodsWe conducted a 13-year longitudinal cohort study incorporating population-wide, sibling, and paternal comparisons. We used nation-wide population-based data on diagnoses and drug prescriptions from the Taiwan National Health Insurance Research Database, with linkages to the Taiwan Birth Certificate Registration and the Taiwan Maternal and Child Health Database between 2004 and 2016. We obtained data on live births to mothers exposed or unexposed to benzodiazepine. Children born by the same mother without benzodiazepine exposures before or during pregnancy were ascertained to create the sibling comparison cohort. We also gathered information on newborns with benzodiazepine-exposed or unexposed fathers. We determined the risks of subsequent PTB and SGA during the 13-year follow-up period.

resultsWe included data on 2 572 125 births to mothers exposed to benzodiazepine and 2 265 685 births to mothers unexposed to benzodiazepine. After adjustments and from our sibling comparison group, the increased risks of preterm births (odds ratio [OR] 1.71, 95% confidence interval [CI] 1.53-1.91) and SGA (OR 1.47, 95% CI 1.14-1.89) were significant only among children born from mothers exposed to benzodiazepine in the third trimester. LIMITATIONS: Our results are subject to unmeasured confounding factors, such as smoking and the severity of parental mental illness, which were not available in the administrative claims data.

conclusionBenzodiazepine exposure during the third trimester, but not the first or second trimesters, increased the risks of PTB and SGA. This result may reflect the direct effects of benzodiazepine on fetal development or the intrauterine environment.

Indexed as

BenzodiazepinesInfant, Low Birth WeightPregnancy TrimestersPremature BirthPrenatal Exposure Delayed EffectsAdultFemaleHumansInfant, NewbornInfant, Small for Gestational AgeLongitudinal StudiesMalePregnancyTaiwanBenzodiazepines

Identifiers

PMID40858335
PMCPMC12385125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.