Evidence map›Paper›PMID 40858259›Full record

ArticleProceedings. Biological sciences2025

Keratinization-like differentiation process forms chitinous dermal sclerites in the hot-vent snail

Chong Chen, Satoshi Okada, Hiromi Kayama Watanabe, Katsuyuki Uematsu, Noriyuki Isobe

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chong ChenX-STAR, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Kanagawa 237-0061, Japan.ORCID 0000-0002-5035-4021
Satoshi OkadaX-STAR, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Kanagawa 237-0061, Japan.ORCID 0000-0001-5417-5955
Hiromi Kayama WatanabeX-STAR, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Kanagawa 237-0061, Japan.ORCID 0000-0001-5031-9018
Katsuyuki UematsuMarine Works Japan Ltd., Yokosuka, Kanagawa 237-0063, Japan.ORCID 0000-0001-8461-5608
Noriyuki IsobeBiogeochemistry Research Center, Research Institute for Marine Resources Utilization (MRU), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Kanagawa 237-0061, Japan.ORCID 0000-0001-8571-3373

Funding

Japan Society for the Promotion of Science (JSPS) JP22K19885, JP19K15379SPring-8 Proposal Review Committee 2017A1720, 2017B1767
6 · The paper itself

Abstract

Animals produce diverse hard structures for critical functions such as protection, feeding and detoxification. Most animals use the polysaccharide chitin as a framework for this, while vertebrates have switched to using fibrous proteins like collagen and keratin. Vertebrates make structures like skin and horns through a cellular differentiation process called keratinization where cells accumulating keratin die and compact into hard layers-drastically different from chitinous structures, which are secreted directly by living cells. Here, we report remarkable chitinous dermal sclerites that are not secreted but instead produced by a keratinization-like process, in the deep-sea hot-vent snail

Indexed as

ChitinSnailsAnimalsCell DifferentiationKeratinsChitinKeratinscell differentiationchitinconvergent evolutionGastropodahistologyhydrothermal ventkeratin

Identifiers

PMID40858259
PMCPMC12380485

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.