Evidence map›Paper›PMID 40858250›Full record

ArticleNature2025

Scalable total synthesis of saxitoxin and related natural products.

Yinliang Guo, Yiheng Li, Sihan Chen, Yige Wu, Oscar Poll, Zhouyang Ren, Zhonglin Liu, Roman Vlkolinsky, Michal Bajo, Christopher K Prier and 4 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yinliang Guo *Department of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0009-0004-8118-5357
Yiheng Li *Department of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0009-0004-3944-4781
Sihan ChenDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0009-0009-3272-8040
Yige WuDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Oscar PollDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Zhouyang RenDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Zhonglin LiuDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Roman VlkolinskyDepartment of Translational Medicine, Scripps Research, La Jolla, CA, USA.
Michal BajoDepartment of Translational Medicine, Scripps Research, La Jolla, CA, USA.
Christopher K PrierProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID 0000-0003-0902-1636
Kai-Jiong XiaoProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID 0000-0001-5613-2035
Benjamin F CravattDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0000-0001-5330-3492
Marisa RobertoDepartment of Translational Medicine, Scripps Research, La Jolla, CA, USA. mroberto@scripps.edu.ORCID 0000-0003-0729-3961
Phil S BaranDepartment of Chemistry, Scripps Research, La Jolla, CA, USA. pbaran@scripps.edu.ORCID 0000-0001-9193-9053

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Synaptic Mechanisms underlying sex-differences in alcohol use disorderR01AA029841 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2022 to 2026
$2.0M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA029841NIAAA NIH HHS R37 AA017447NIAAA NIH HHS U01 AA013498NIGMS NIH HHS R35 GM118176
6 · The paper itself

Abstract

Saxitoxin (STX, 1), a potent neurotoxin from shellfish, first isolated in 1957 (ref.

Indexed as

Biological ProductsChemistry Techniques, SyntheticSaxitoxinAnimalsBiocatalysisHydroxylationBiological ProductsneosaxitoxinSaxitoxin

Identifiers

PMID40858250
PMCPMC12781131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.